Nanostructures made of DNA pave way towards functional drugdelivery vehicles

first_img Source:https://www.jyu.fi/en/current/archive/2019/04/dna-folds-into-a-smart-nanocapsule-for-drug-delivery Reviewed by James Ives, M.Psych. (Editor)Apr 29 2019New study shows that nanostructures constructed of DNA molecules can be programmed to function as pH-responsive cargo carriers, paving the way towards functional drug-delivery vehicles.Researchers from University of Jyväskylä and Aalto University in Finland have developed a customized DNA nanostructure that can perform a predefined task in human body-like conditions. To do so, the team built a capsule-like carrier that opens and closes according to the pH level of the surrounding solution. The nanocapsule can be loaded—or packed—with a variety of cargo, closed for delivery and opened again through a subtle pH increase.The function of the DNA nanocapsule is based on pH-responsive DNA residues.To make this happen, the team designed a capsule-like DNA origami structure functionalized with pH-responsive DNA strands. Such dynamic DNA nanodesigns are often controlled by the simple hydrogen-bonding of two complementary DNA sequences. Here, one half of the capsule was equipped with specific double-stranded DNA domains that could further form a DNA triple helix — in other words a helical structure comprised of three, not just two DNA molecules — by attaching to a suitable single-stranded DNA in the other half.’The triplex formation can happen only when the surrounding pH of the solution is right. We call these pH-responsive strands “pH latches”, because when the strands interact, they function similarly to their macroscopic counterparts and lock the capsule in a closed state. We included multiple motifs into our capsule design to facilitate the capsule opening/closing based on cooperative behaviour of the latches. The opening of the capsule is actually very rapid and requires only a slight pH increase in the solution”, explains first author of the study, doctoral student Heini Ijäs from Nanoscience Center at University of Jyvaskyla..Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsUCR scientists decode genome of black-eyed peasSlug serves as ‘command central’ for determining breast stem cell healthNanoparticles and enzymes could be loaded and encapsulated within the capsulesTo harness the nanocapsules for transporting molecular payloads or therapeutic substances, the team designed the capsule with a cavity that could host different materials. They demonstrated that both gold nanoparticles and enzymes could be loaded (high pH) and encapsulated within the capsules (low pH) and again displayed (high pH). By monitoring the enzyme activity, the researchers found that the cargo remained fully functional over the course of the process.’The most intriguing thing about the DNA origami capsules is that the threshold pH at which the opening and closing take place is fully adjustable by selecting the base sequences of the pH latches. We designed the threshold pH to be 7.2-7.3, close to the blood pH. In the future, this type of drug carrier could be optimized to selectively open inside specific cancer cells, which can maintain a higher pH than normal healthy ones,’ says Veikko Linko, Adjunct Professor at Aalto University.Further, the capsules remained functional at physiological magnesium and sodium concentrations, and in 10% blood plasma, and may continue to do at even higher plasma concentrations. Together, these findings help pave the way for developing smart and fully programmable drug-delivery vehicles for nanomedicine. last_img read more

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A novel way to encapsulate islet cells for treatment of diabetes

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 27 2019When medical devices are implanted in the body, the immune system often attacks them, producing scar tissue around the device. This buildup of tissue, known as fibrosis, can interfere with the device’s function.MIT researchers have now come up with a novel way to prevent fibrosis from occurring, by incorporating a crystallized immunosuppressant drug into devices. After implantation, the drug is slowly secreted to dampen the immune response in the area immediately surrounding the device.”We developed a crystallized drug formulation that can target the key players involved in the implant rejection, suppressing them locally and allowing the device to function for more than a year,” says Shady Farah, an MIT and Boston Children’s Hospital postdoc and co-first author of the study, who is soon starting a new position as an assistant professor of the Wolfson Faculty of Chemical Engineering and the Russell Berrie Nanotechnology Institute at Technion-Israel Institute of Technology.The researchers showed that these crystals could dramatically improve the performance of encapsulated islet cells, which they are developing as a possible treatment for patients with type 1 diabetes. Such crystals could also be applied to a variety of other implantable medical devices, such as pacemakers, stents, or sensors.Former MIT postdoc Joshua Doloff, now an assistant professor of Biomedical and Materials Science Engineering and member of the Translational Tissue Engineering Center at Johns Hopkins University School of Medicine, is also a lead author of the paper, which appears in the June 24 issue of Nature Materials. Daniel Anderson, an associate professor in MIT’s Department of Chemical Engineering and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science (IMES), is the senior author of the paper.Crystalline drugAnderson’s lab is one of many research groups working on ways to encapsulate islet cells and transplant them into diabetic patients, in hopes that such cells could replace the patients’ nonfunctioning pancreatic cells and eliminate the need for daily insulin injections.Fibrosis is a major obstacle to this approach, because scar tissue can block the islet cells’ access to the oxygen and nutrients. In a 2017 study, Anderson and his colleagues showed that systemic administration of a drug that blocks cell receptors for a protein called CSF-1 can prevent fibrosis by suppressing the immune response to implanted devices. This drug targets immune cells called macrophages, which are the primary cells responsible for initiating the inflammation that leads to fibrosis.”That work was focused on identifying next-generation drug targets, namely which cell and cytokine players were essential for fibrotic response,” says Doloff, who was the lead author on that study, which also involved Farah. He adds, “After knowing what we had to target to block fibrosis, and screening drug candidates needed to do so, we still had to find a sophisticated way of achieving local delivery and release for as long as possible.”In the new study, the researchers set out to find a way to load the drug directly into an implantable device, to avoid giving patients drugs that would suppress their entire immune system.Related StoriesMetformin use linked to lower risk of dementia in African Americans with type 2 diabetesUranium toxicity might have caused obesity and diabetes in Kuwait, finds new studyNew biomaterial could encapsulate and protect implanted insulin-producing cells”If you have a small device implanted in your body, you don’t want to have your whole body exposed to drugs that are affecting the immune system, and that’s why we’ve been interested in creating ways to release drugs from the device itself,” Anderson says.To achieve that, the researchers decided to try crystallizing the drugs and then incorporating them into the device. This allows the drug molecules to be very tightly packed, allowing the drug-releasing device to be miniaturized. Another advantage is that crystals take a long time to dissolve, allowing for long-term drug delivery. Not every drug can be easily crystallized, but the researchers found that the CSF-1 receptor inhibitor they were using can form crystals and that they could control the size and shape of the crystals, which determines how long it takes for the drug to break down once in the body.”We showed that the drugs released very slowly and in a controlled fashion,” says Farah. “We took those crystals and put them in different types of devices and showed that with the help of those crystals, we can allow the medical device to be protected for a long time, allowing the device to keep functioning.”Encapsulated islet cellsTo test whether these drug crystalline formulations could boost the effectiveness of encapsulated islet cells, the researchers incorporated the drug crystals into 0.5-millimeter-diameter spheres of alginate, which they used to encapsulate the cells. When these spheres were transplanted into the abdomen or under the skin of diabetic mice, they remained fibrosis-free for more than a year. During this time, the mice did not need any insulin injections, as the islet cells were able to control their blood sugar levels just as the pancreas normally would. In the past three-plus years, our team has published seven papers in Nature journals — this being the seventh — elucidating the mechanisms of biocompatibility. These include an understanding of the key cells and receptors involved, optimal implant geometries and physical locations in the body, and now, in this paper, specific molecules that can confer biocompatibility. Taken together, we hope these papers will open the door to a new generation of biomedical implants to treat diabetes and other diseases.”Robert Langer, the David H. Koch Institute Professor at MIT and an author of the paper The researchers believe that it should be possible to create crystals that last longer than those they studied in these experiments, by altering the structure and composition of the drug crystals. Such formulations could also be used to prevent fibrosis of other types of implantable devices. In this study, the researchers showed that crystalline drug could be incorporated into PDMS, a polymer frequently used for medical devices, and could also be used to coat components of a glucose sensor and an electrical muscle stimulation device, which include materials such as plastic and metal.”It wasn’t just useful for our islet cell therapy, but could also be useful to help get a number of different devices to work long-term,” Anderson says. Source:Massachusetts Institute of Technologylast_img read more

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Yearlong birth control supply could be costeffective prevent undesired pregnancies

first_imgRelated StoriesIt is okay for women with lupus to get pregnant with proper care, says new studyTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTGender biases are extremely common among health care professionalsVA data shows that 43% of women receiving three-month increments of birth control pills experience at least one gap between refills over the course of a year of use. Outside the VA, women who get a year’s worth of birth control pills up front experience fewer gaps, and ultimately, fewer unintended pregnancies.Since the VA doesn’t yet offer the option of dispensing a 12-month supply, Judge-Golden analyzed how expensive such a program would be, together with senior author Sonya Borrero, M.D., M.S., director of Pitt’s Center for Women’s Health Research and Innovation and associate director of the VA’s Center for Health Equity Research and Promotion.The researchers estimate that among the approximately 24,000 women receiving oral contraceptives from the VA, offering a year’s supply of pills would prevent 583 unintended pregnancies and save the VA about $2 million a year in prenatal, birth and newborn care costs.”We see extended contraceptive dispensing as a win-win,” said Judge-Golden, “promoting women’s health and women’s autonomy to use birth control as they decide, while also being economically sustainable for the VA.”To date, 17 states and the District of Columbia have passed laws requiring insurers to cover a year’s supply of contraceptives. As the largest integrated American health system, the VA has an opportunity to deploy this evidence-based policy on a national scale.”This is a great opportunity for the VA to roll out this policy change on a national level and continue to be a leader and set an elevated standard for women’s health care,” Borrero said. Source:Health Sciences at the University of PittsburghJournal reference:Judge-Golden, C.P. et al. (2019) Financial Implications of 12-Month Dispensing of Oral Contraceptive Pills in the Veterans Affairs Health Care System. JAMA Internal Medicine. doi.org/10.1001/jamainternmed.2019.1678. Reviewed by Kate Anderton, B.Sc. (Editor)Jul 8 2019New research from the University of Pittsburgh and the U.S. Department of Veterans Affairs (VA) shows that dispensing a year’s supply of birth control pills up front would support women’s reproductive autonomy while also being cost effective.The paper, published today in JAMA Internal Medicine, used a mathematical model to demonstrate that reducing birth control refills would better allow female veterans to prevent undesired pregnancies, and the money saved on health care costs would more than outweigh the expense of providing birth control in larger quantities. Medication dispensing limits are thought to be cost-saving because you’re not wasting pills and medicines that people aren’t going to use. Our analysis shows that concerns about wastage of contraceptive pills are overshadowed by the potential consequences of missed refills, and especially of unintended pregnancies.”Colleen Judge-Golden, M.D., Ph.D. student at Pitt’s School of Medicine, lead authorlast_img read more

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Shhh How to stream March Madness when the boss isnt around

This undated product image provided by Turner Broadcasting System, Inc. shows the NCAA March Madness Live app on an iPhone. The men’s college basketball tournament begins Tuesday, March 13, 2018. All 67 games will be available online. Many of the games, including the Final Four, will require a password through your cable or satellite TV subscription. (Turner Broadcasting System, Inc. via AP) Fortunately for you—though not your boss—all 67 games in the NCAA men’s college basketball tournament will be available online. Many of the games, including the Final Four, will require a password through your cable or satellite TV subscription.Among the changes this year: a special stream to get the hot moments live when multiple games are played simultaneously during the first round. There are also new ways to subscribe to online TV packages, which stream many of the channels you’d get from a cable subscription.Here’s a viewer’s guide:___HAPPY STREAMINGThe best places to watch: www.ncaa.com/marchmadness or the NCAA March Madness Live app. All the games will be there, regardless of where they are televised.CBS is televising 21 games, including two of the quarterfinals. These games won’t require a cable or satellite password. To view on a streaming device such as Apple TV, Roku or Fire TV, you need a $6-a-month subscription to CBS All Access, or a subscription to one of those cable-like online packages.You’ll need a password for the remaining games, which are split among the Turner-owned cable channels—TBS, TNT and truTV. That includes the semifinals and championship game, known collectively as the Final Four. There’s a three-hour grace period on most devices. Games also will be available on individual apps for TBS, TNT and truTV—again with a password. Explore further This undated product image provided by Turner Broadcasting System, Inc., shows the March Madness Live service on Amazon’s Fire TV, with a feature for easily switching between games. The men’s college basketball tournament begins Tuesday, March 13, 2018. All 67 games will be available online. To view on a streaming device such as Apple TV, Roku or Fire TV, you need a $6-a-month subscription to CBS All Access, or a subscription to one of those cable-like online packages. (Turner Broadcasting System, Inc. via AP) This undated product image provided by Turner Broadcasting System, Inc. shows March Madness Live on a laptop. The men’s college basketball tournament begins Tuesday, March 13, 2018. All 67 games will be available online. On desktops and laptops, the March Madness website will have a “boss button.” One click replaces the game with a fake screenshot of a search engine, spreadsheet or PowerPoint-like app, your choice, but set it up ahead of time. (Turner Broadcasting System, Inc. via AP) On desktops and laptops, the March Madness website will have a “boss button.” One click replaces the game with a fake screenshot of a search engine, spreadsheet or PowerPoint-like app—your choice, but set it up ahead of time.___NO PASSWORD?Consider subscribing to an online television package. These packages will let you watch through the service directly or through the March Madness Live app and website.There are some new ones since last year’s tournament, including Google’s YouTube TV and Hulu with Live TV, joining AT&T’s DirecTV Now and Sony’s PlayStation Vue from before. The services cost $35 or $40 a month. Dish’s Sling TV costs $25, but doesn’t come with CBS. A sports-focused service, fuboTV, has CBS but not the Turner networks, so strike that. March Madness begins Tuesday. And that may mean strategizing to sneak in some games when the boss isn’t looking. The March Madness app on Apple TV also offers three games simultaneously, up from two last year.Otherwise, you can have multiple browser tabs open or watch simultaneously on a phone and a personal computer.A new feature called Fast Break will switch from game to game automatically during the first round, depending on the action. It’s similar to the NFL RedZone or the Olympics’ Gold Zone. It’s available through the March Madness app on various devices and browsers.With Hulu, you can choose your favorite teams, and its live-TV service will send phone alerts and automatically record games involving those teams. Those with the basic Hulu service, without the live channels, will get condensed versions of games after they end.___HEARING ITWestwood One’s radio coverage of all games will be available with no password needed. You can also get this on Amazon’s Echo devices by asking the Alexa digital assistant for the score.___VIRTUAL REALITYIntel will be producing some games in virtual reality. This time, it’ll work with Google Daydream headsets as well, not just Samsung’s Gear VR. Details on prices and the specific games haven’t been announced yet. Keep in mind that VR is no replacement for television; TV can get you much closer to the action with camera zooms than VR, which typically anchors you in a fixed location. All NFL games will air online, but watching won’t be easy This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Even services that include CBS might not offer the local CBS station where you live. Check before you subscribe by entering your ZIP code. To get CBS, you can also subscribe to All Access or use an antenna.___KEEPING UPWith Vue on a PlayStation 4 device, you can watch three channels on the same screen at once. This means you can keep up with games being televised simultaneously on different channels, or have a talk show taking up one of the three streams. Vue offers just one game at a time on other devices. Citation: Shhh! How to stream March Madness when the boss isn’t around (2018, March 12) retrieved 18 July 2019 from https://phys.org/news/2018-03-shhh-stream-madness-boss-isnt.html © 2018 The Associated Press. All rights reserved. read more

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Big tech firms agree on data portability plan

first_img © 2018 AFP Social network users will be able to download their personal data and transfer it to a different service user a “data portability” plan unveiled by tech giants Facebook, Google, Microsoft and Twitter Citation: Big tech firms agree on ‘data portability’ plan (2018, July 20) retrieved 18 July 2019 from https://phys.org/news/2018-07-big-tech-firms-portability.html Explore further The “Data Transfer Project” revealed by the companies responds to concerns about the growing influence of internet platforms and internet user concerns about control of their personal information shared online.”Users should be in control of their data on the web, part of this is the ability to move their data,” the companies said on the project website.Data portability has been a goal of many privacy activists, and is enshrined in some country regulations including Europe’s new General Data Protection Regulation.Currently, people can download their data from an online service, without a guarantee it will be possible or feasible to upload the information to a new service.The situation can result in people feeling anchored to a service or app, even if they are unhappy with it or an enticing option arises, because of photos, contacts, posts and other accumulated data.”Making it easier for individuals to choose among services facilitates competition, empowers individuals to try new services and enables them to choose the offering that best suits their needs,” the project said at its website.”There are many use cases for users porting data directly between services, some we know about today, and some we have yet to discover.”Reasons for shifting personal data could include abandoning an old service, trying a new one, or simply backing up information to keep it safe.The project was formed two years ago and remains in a development phase.Disclosure of the effort comes amid heightened scrutiny over the potential of internet companies to abuse positions of power and the right of people to control their online data.center_img Facebook, Google ‘manipulate’ users to share data despite EU law: study This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Facebook, Google, Microsoft and Twitter unveiled plans Friday to make it easier for users to take their personal data and leave one online service for another.last_img read more

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This new invention can generate power from the softest breeze

first_img Using low-velocity winds—less than nine miles per hour, which are not strong enough to turn a traditional wind turbine’s blades—the new generator creates power using “elastic tension gradient” strips.The prototype generator, built at the Corps’ Engineer Research and Development Center, has a base structure made of PVC piping that supports eight elastic strips mounted vertically on rotating tensioning tubes.The strips are positioned in parallel with the wind’s direction and their front-to-back elasticity gives them a constant serpentine wiggle, which moves an embedded copper induction coil across a smooth pipe containing magnets. Wiring transmits the induced electricity from the coil generators to a power converter and output where it can be used for all sorts of work.Optionally, guide planes can be attached to funnel more air current over the flaps and a stiffening bar can be added to at the midpoint of the elastic flaps, which “enhances the generation of serpentine motion by providing an increased surface area for the fluid without hindering the serpentine motion,” according to the patent. Citation: This new invention can generate power from the softest breeze (2019, April 12) retrieved 17 July 2019 from https://phys.org/news/2019-04-power-softest-breeze.html Axy Pagan-Vasquez, a mechanical engineer with the U.S. Army Corps of Engineers, explains how low-velocity wind energy is being captured using flexible strips of material during the Department of Defense Lab Day at the Pentagon. The US Army Corps of Engineers’ Engineer Research and Development Center is developing the technology for use in conditions beyond suitable for wind turbines. Credit: EJ Hersom/DoD New offshore wind turbine boosts energy yield by nearly ten percent Provided by TechLink The Army’s patent lists 10 inventors: Charles Marsh, Axy Pagan-Vazquez, Carl Feickert, Aaron Averbuch, Meredith Sellers, Christopher Joel Foster, Scott Lux, Justin Hesterberg, Andy Friedl, and John Alexander Magerko, III.In a 2014 report, Marsh and Feickert wrote that the idea for the fluid generator was initially inspired by “common Venetian blinds, fluttering in the gentle breeze of an open window…”In coordination with the Army’s technology transfer program, Marti Elder, a senior technology manager at TechLink and invention licensing expert, is seeking entrepreneurs or businesses that would make, use, or sell the generator commercially.Elder said that the Corps of Engineers’s technology, scaled up, could expand the geographic boundaries of wind energy production to places with historically low winds, and noted that the blade-less design has a reduced impact on birds and bats.”The market for renewable energy isn’t going away, and neither is the military’s interest in powering expeditionary forces,” she said. “With a working prototype, the business opportunity is evident and exciting.” An Army cadet lifts an early prototype of the invention, dubbed the Flutter Mallard, at the Engineering Research Development Center’s Forward Operating Base Laboratory in Champaign, Illinois. Credit: Army photo A patent was issued to the U.S. Army Corps of Engineers on Tuesday for a novel generator that buzzes in a light breeze. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: U.S. Patent 10,256,698: techlinkcenter.org/wp-content/ … generator-system.pdflast_img read more

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Post Air India incident DGCA bars offduty crew members from travelling in

first_img Next Press Trust of India New DelhiJuly 16, 2019UPDATED: July 16, 2019 03:16 IST The DGCA said all airline operators were directed to ensure that no travel in cockpit is permitted in violation of AIC 3 of 1997.Aviation regulator DGCA on Monday barred airline officials, including pilots and aircraft maintenance engineers, from travelling in the cockpit when they were off-duty or on leave.The regulator’s directions came after an off-duty pilot of Air India tested positive in a pre-flight alcohol test on Saturday when he was scheduled to travel in the cockpit of a plane from Delhi to Bengaluru.The Directorate General of Civil Aviation (DGCA) has asked the national carrier to take strict action against the pilot.This practice of off-duty or on leave officials is in violation of the Aeronautical Information Circular (AIC) 3 of 1997, it said.The DGCA also said this practice “provides cover to officials who are authorised to travel in the cockpit while on leave or off-duty and detected BA (breath-analyzer) positive.”In an order, the regulator said it has come to its notice that the Operations Manual Part-A of Air India permits travel of airline officials such as pilots and AMEs (aircraft maintenance engineers) in cockpit “even when they are on leave or have not been assigned any duty whatsoever prescribed in AIC 3 of 1997.”The regulator added, “The portion of the Operations Manual Part-A so far as it is in violation of AIC 3 of 1997, is void ab-initio and stands repudiated with immediate affect.””All airline operators are hereby directed to amend their Operations Manual Part-A to align with AIC 3 of 1997 with regard to travel in cockpit and submit to the DGCA for approval,” it said.The DGCA said all airline operators were directed to ensure that no travel in cockpit is permitted in violation of AIC 3 of 1997.AIC 3 of 1997, issued by the DGCA, clearly states that airline official can take the extra seat (called jump seat) in the aircraft only in certain specific conditions such as “when necessary for safe operation of aircraft” or “better practical understanding and knowledge of the functions of the instruments.”Also Read | DGCA suspends Air India pilot for six months for physical altercation with cabin crew memberAlso Watch | Plane with Justice for Kashmir banner flies over Headingley stadium during India-Sri Lanka matchFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAkriti Anand Tags :Follow Air India Post Air India incident, DGCA bars off-duty crew members from travelling in cockpitAviation regulator DGCA barred airline officials, including pilots and aircraft maintenance engineers, from travelling in the cockpit after an off-duty pilot of Air India was tested positive in a pre-flight alcohol test on Saturday.advertisementlast_img read more

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Mumbai building collapse Dramatic visuals show NDRF rescuing woman from rubble

first_img Next Mumbai building collapse: Dramatic visuals show NDRF bringing out woman as she struggles to breatheA four-storey building in Mumbai’s Dongri area collapsed on Tuesday, killing at least 4 people so far.advertisement India Today Web Desk New DelhiJuly 16, 2019UPDATED: July 16, 2019 17:11 IST A woman being rescued by NDRF personnel from the debris. (Screen grab: ANI)As a four-storey building in south Mumbai’s congested Dongri area collapsed on Tuesday, NDRF rescued a woman from the rubble in a miraculous operation, several hours after the accident.In a video released by news agency ANI, rescue personnel can be seen lending a hand to each other to bring out the woman from the middle of the debris as she struggles to breathe.So far, at least 4 people have been confirmed as dead in the major accident that shook the congested lanes of Mumbai. Over 40 people are still feared trapped in the rubble. Rescue officials believe the toll may further go up as they struggle to bring out the trapped men and women.#WATCH Mumbai: A woman being rescued by NDRF personnel from the debris of the building that collapsed in Dongri, today. 2 people have died & 7 people have been injured in the incident. #Maharashtra pic.twitter.com/tmzV3Dmm7CANI (@ANI) July 16, 2019FOLLOW LIVE UPDATES ON MUMBAI BUILDING COLLAPSEAccording to PTI, civic officials have said that at least 12 people have died so far.Dramatic visuals showed visuals of a child, wrapped in a cloth bundle, being carried out of the debris by rescue workers. The child is alive, officials said.Meanwhile, Mumbadevi MLA Amin Patel told reporters that officials are assuming that over 10-12 families are still trapped under the debris.Chief Minister Devendra Fadnavis said the building was around 100 years old. It was not in the list of dilapidated buildings and was given to a developer for redevelopment.Between 10 and 15 families lived in the building, he said.Locals said the building belonged to the Maharashtra Housing and Area Development Authority (MHADA). However, Vinod Ghosalkar, chief of MHADA repair board, said the building did not belong to the housing body.Legislator Bhai Jagtap said residents had complained to housing authorities to take prompt measures as the building was very old and in a dilapidated state for a long time.Some part of the building was left standing after the collapse.(With PTI inputs)Also Read | Four-storey building collapses in Mumbai, over 40 trappedFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySanchari Chatterjeelast_img read more

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Amazon Prime Day Best Health Fitness Deals

first_imgPrime Day, Amazon’s day of deals, is here. To help you make the most of it, we’ve rounded up some of Amazon’s best deals on health and fitness products, both practical and quirky.  Folding Pedal Exerciser This pedal exerciser is a great way to exercise and improve blood circulation while sitting at a desk or on a couch, and it folds up for easy storage and carrying.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/63073-amazon-prime-day-best-health-fitness-deals.html?jwsource=cl已复制直播00:0000:3500:35  Prime Day price: $25.49, a savings of 25% for Prime members Buy Folding Pedal Exerciser on Amazon.com Portable Air Purifier The Airdog FitAir Portable Air Purifier with HEPA Filter will continuously clean the air in a 25-square-foot (2-square-meter) area, filtering pollen, smoke, and other particles. The filter typically lasts for 1 to 2 months in a polluted environment and for 2 to 4 months when pollution is low. Prime Day price: $79.20, a savings of 20% for Prime members Buy Portable Air Purifier on Amazon.com Dog Frisbee and Rope Toy Exercise and have fun with your dog with this ring frisbee and rope toy set. Both items are made of durable, nontoxic rubber and the rope is heavy nylon. Prime Day price: $24.79, a savings of 20% for Prime members Buy Dog Frisbee and Rope Toy on Amazon.com White Noise Sound Machine Drift off to sleep while listening to soothing recorded sounds that mimic six natural soundscapes: Rain, Ocean, Brook, Summer Night, Thunder and White Noise. This white noise machine is lightweight and portable and can be plugged into a wall outlet or powered by four AA batteries (not included). Prime Day price: $19.99, a savings of 20% for Prime members. Save an additional 30% on this item at checkout. Buy White Noise Sound Machine on Amazon.com Ergonomic Foot Rest Improve your posture and foot circulation during extended periods of sitting, with this adjustable under-desk foot rest. The surface is molded to provide stability and to massage pressure points on your feet, while 5 angles and heights allow you to customize the position for maximum comfort. Prime Day price: $21.59, a savings of 20% for Prime members Buy Ergonomic Foot Rest on Amazon.com Full Body Pillow The shape of this full body pillow provides support for back, knees and belly during pregnancy and post-surgery. Prime Day price: $43.19, a savings of 20% for Prime members Buy Full Body Pillow on Amazon.com 23andMe DNA Test Investigate your genetic heritage by submitting a saliva sample that you collect with this kit at home. Results arrive in 6 to 8 weeks. Prime Day price: $99.99, a savings of 50% for Prime members Buy 23andMe DNA Test on Amazon.com Pet Fitness Robot This robot provides stimulation and exercise for your housebound pet, interacting with it through motion detection sensors, and dispensing treats. It also tracks their activity, so you can monitor your pet’s fitness. The robot “can hold up to tough chewers and can get a little wet,” according to the manufacturers. Prime Day price: $101.40, a savings of 40% for Prime members Buy Pet Fitness Robot on Amazon.com Fitness Activity Tracker  Track your heart rate, blood pressure, menstrual cycle and more with a waterproof Bluetooth fitness tracker, controlled by a smartphone running iOS 8.1 and Android 4.4 and above (not for PC, iPad or tablets).  Prime Day price: $36.79, a savings of 20% for Prime members Buy Fitness Activity Tracker on Amazon.com Gaiam Reversible Yoga Mat Available in 38 colorful patterns, this thick, reversible yoga mat is lightweight, nonslip and durable, and is suitable for yoga, pilates and other floor exercises. Prime Day price: $26.25, a savings of 25% for Prime members Buy Gaiam Reversible Yoga Mat on Amazon.com Insulated Squeeze Bottle This easy-to-clean bottle holds 17 ounces (0.5 liters) and has double-walled construction, to keep water cold longer. Prime Day price: $15.00, Prime members save an additional 20% at checkout Buy Insulated Squeeze Bottle on Amazon.com Personal Single-Serving Blender  Whip up smoothies, healthy shakes or even baby food with this portable, single-serving and BPA-free blender. Built-in lithium batteries charge via USB, and the blender can be used 10-15 times on a single charge. Prime Day price: $25.27, a savings of 21% for Prime members Buy Personal Blender  on Amazon.com Canine Genetic Test A simple DNA test will determine all of the breeds that make up your dog’s genetic heritage, and will also pinpoint their age. Prime Day price: $68.98, a savings of 31% for Prime members Buy Canine Genetic Test on Amazon.com Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoSecurity SaversWindows Users Advised To Do This TodaySecurity SaversUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndoNucificTop Dr. Reveals The 1 Nutrient Your Gut Must HaveNucificUndolast_img read more

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Opposition rallies around Naidu

first_imgGovt should fulfil promise of special status to Andhra without delay: Manmohan Singh Will make AP one of 3 best States by 2022: CM Andhra Pradesh PM stole from Andhra Pradesh and gave it to Anil Ambani: Rahul Gandhi Published on COMMENT At the day-long protest in Delhi, parties flay Modi; back demand for special status to AP After West Bengal Chief Minister Mamata Banerjee, it was the turn of Andhra Pradesh Chief Minister N Chandrababu Naidu to rally the Opposition parties against the ruling BJP in the Capital for a day-long fast demanding special status for his State on Monday.Kejriwal criticises PMFrom Delhi Chief Minister Arvind Kejriwal who claimed that Prime Minister Narendra Modi “behaves like the Prime Minister of Pakistan when he deals with chief ministers from Opposition parties”, to former Prime Minister Manmohan Singh to Congress President Rahul Gandhi, a host of Opposition leaders, including National Congress (NC) chairperson Farooq Abdullah, Nationalist Congress Party’s Majeed Memon, Trinamool Congress’ Derek O’ Brien, DMK’s Tiruchi Siva and Samajwadi Party founder Mulayam Singh Yadav gathered in front of Andhra Bhawan in the Capital to lend support to Naidu.“Prime Minister Narendra Modi is now world famous for lying. He has consistently lied, even in front of Tirupati Balaji, about giving special status to Andhra Pradesh… He treats chief ministers from other political parties like he is the Prime Minister of Pakistan. I salute Mamata di (Mamata Banerjee) for resisting the PM’s assault on federalism. He sent the CBI after Kolkata police chief like he had sent the paramilitary forces for Delhi’s anti-corruption branch. I want to tell him that he is not the PM of the BJP. He is the PM of India,” said Kejriwal.Former PM Manmohan Singh said the demand for special status to Andhra Pradesh had the support of all parties when it was discussed in Parliament. “I stand in solidarity with Naidu. Special category status promise must be implemented without any further delay,” said the former PM. ‘Unkept promise’The AP CM and Telugu Desam Party President demanded that the Centre fulfil promises made during the State’s bifurcation in 2014, and alleged that Modi was not following ‘raj dharma’ by denying  special status. Naidu’s ‘Dharma Porata Deeksha’ (a day-long protest for justice), which began at 8, ended in the evening and he is likely to submit a memorandum to President Ram Nath Kovind on February 12. Naidu paid tributes to Mahatma Gandhi at Raj Ghat and also to the Ambedkar Statue at the Andhra Pradesh Bhavan before sitting on the hunger strike.The Congress President raised the issue of alleged corruption in the Rafale jet fighter deal when he spoke at the  protest venue. “The Prime Minister has stolen from the people of  Andhra Pradesh and he has given that money to Anil Ambani. That is the fact of the matter,” Gandhi said.TMC’s Derek O’Brien recalled Modi’s speech in Guntur, Andhra Pradesh, on Sunday and said he didn’t talk about development or special category status but “started a personal attack”. “Those who live in glass houses should not throw stones at others,” he said. The PM said in his rally that Naidu was indeed a senior, but only in losing elections, switching alliances and ditching his father-in-law NT Rama Rao.Lashing out at the PM, NC’s Farooq Abdullah said, “Modi has stooped so low that he’s making personal attacks against Naidu, who is doing a great service to the country.” Chandrababu Naidu begins day-long fast over special status to Andhra Pradesh RELATED center_img Andhra Pradesh Chief Minister N Chandrababu Naidu participates in a day-long fast at the Andhra Bhavan, New Delhi, February 11, 2019   –  Kamal Narang SHARE state politics SHARE SHARE EMAIL To get ‘special status’ for AP, Naidu to protest in Delhi February 11, 2019 COMMENTSlast_img read more

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Sonia Priyanka visit Raebareli for thanking voters

first_img UPA chairperson Sonia Gandhi and her daughter and Congress general secretary Priyanka Gandhi Vadra on Wednesday arrived here on a thanks-giving visit. This is their first visit to the constituency after it elected Sonia Gandhi in the Lok Sabha polls. District Congress spokesperson Lal Aash Kiran Pratap Singh the two leaders landed the Fursatganj airport here after which their cavalcade reached Bhuyemau guest house. Priyanaka Gandhi is likely to hold review meeting with district chiefs of the area at the guest house, he said. In the evening, there will be a thanks-giving ceremony for which over 2,500 party workers have been invited, he said. elections Lok Sabha Published on June 12, 2019 COMMENTScenter_img SHARE SHARE EMAIL SHARE politics COMMENTlast_img read more

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Small quake jolts Mexico City no immediate reports of damages

first_img Related News Related News World 17 Jun 2019 ‘Explosion’ near China-North Korea border causes small quake World 30 Jun 2019 ‘Here, I feel free’: Mexico City celebrates role as haven for LGBTQ migrants MEXICO CITY (Reuters) – A small earthquake struck central Mexico City on Friday morning, jolting office towers and apartment buildings in the sprawling metropolis. A temblor of magnitude 2.5 was registered in the central neighbourhood of Alvaro Obregon at 7:38 am, the National Seismological Service wrote in a post on Twitter. There were no immediate reports of damages. The city’s civil protection authority confirmed the magnitude and said they did not activate the local earthquake alarm due to the small size of the temblor.Situated at the intersection of three tectonic plates, Mexico is one of the world’s most earthquake-prone countries, and the capital is particularly vulnerable due to its location on top of an ancient lake bed.center_img Tech News 08 Jul 2019 Electric scooters zip into traffic chaos in Latin America (Reporting by Julia Love and Rebekah F Ward; Editing by Susan Thomas) {{category}} {{time}} {{title}}last_img read more

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Mobile phone explosion injures 30yearold in Tamil Nadu

first_img Lokpria Vasudevan KrishnagiriJuly 15, 2019UPDATED: July 15, 2019 13:38 IST (Image for Representation)In a freak accident, a mobile phone exploded and injured a 30-year-old man while he was riding his bike and talking on the phone. The incident took place on Sunday in Tamil Nadu’s Krishnagiri district.Arumugam, a resident of Shoolagiri, was riding his two-wheeler on the Krishnagiri-Bengaluru highway. He was speaking on his phone, which was placed inside his helmet. When the phone exploded, he lost control of his bike and fell on the ground. He sustained injuries on his face and lost consciousness.Passersby on the highway who witnessed the incident admitted Arumugam to a private hospital. He was later shifted to the government hospital in Krishnagiri for further treatment. While Arumugam regained consciousness, he is still in a state of shock.According to the police, Arumugam was talking on the phone for half an hour, which could have probably caused the phone to heat up. He had purchased the branded phone from a reputed company. The phone is still within the warranty period.The Shoolagiri police has registered a case and are conducting further investigations.ALSO READ: Smartphone battery explodes while charging in Madhya Pradesh, kills 12-year old ALSO WATCH: Bomb found in UP Assembly: CM Adityanath proposes bags, phones not be taken inside Vidhan Sabha For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShreya Sinha Mobile phone explosion injures 30-year-old in Tamil NaduIn a freak accident, a mobile phone exploded and injured a 30-year-old man while he was riding his bike and talking on the phone.advertisement Nextlast_img read more

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HC grants bail to journalist Upendra Rai in money laundering case

first_img Press Trust of India New DelhiJuly 12, 2019UPDATED: July 12, 2019 22:12 IST The Central Bureau of Investigation (CBI) had arrested him on May 3, 2018. (File photo)The Delhi High Court has granted bail to journalist Upendra Rai, arrested in a money laundering case related to alleged extortion and dubious financial transactions, noting that he has already spent more than 13 months in custody and the trial is likely to take some time.Justice Mukta Gupta granted the relief to Upendra Rai on furnishing a personal bond of Rs one lakh with a surety of like amount and directed him not to influence any witness or tamper with the evidence of the prosecution.The court also said he shall not leave the country without prior permission.Upendra Rai was arrested on June 8, 2018, by the Enforcement Directorate under the Prevention of Money Laundering Act (PMLA) at the Tihar jail here, moments after he secured bail in a Central Bureau of Investigation case related to alleged extortion and dubious financial transactions.The Central Bureau of Investigation (CBI) had arrested him on May 3, 2018.The Enforcement Directorate opposed his bail plea saying that merely because bail has been granted to him in the two predicate offences investigated by the Central Bureau of Investigation (CBI) could not be the sole criteria to grant him the relief in the money laundering case.A trial court had in January declined to grant him bail in the case.The high court said since Upendra Rai has already undergone more than one year of custody and there being no material placed on record to show that he has tampered evidence, it is a fit case of granting bail to him.”The maximum punishment provided for the offence punishable under Section 4 Prevention of Money Laundering (PMLA) being seasons years imprisonment and the petitioner has undergone more than 1 year 1 month of custody and the trial likely to take some time, there being no material placed on record to show that the petitioner has been tampering of evidence… this court finds it to be a fit case for grant of bail to the petitioner,” the judge said.During the previous hearing, the Delhi-based scribe’s counsel had alleged in the high court that investigating agencies, Central Bureau of Investigation (CBI) and Enforcement Directorate (ED), were “playing with the liberty” of his client.The lawyer had said that the “vindictive approach” of the agencies was evident from the fact that he was being kept in custody even though his further interrogation was not required.Upendra Rai was arrested by the Central Bureau of Investigation (CBI) for allegedly indulging in dubious financial transactions, getting an airport access pass made by the Bureau of Civil Aviation Security (BCAS) by furnishing false information, alleged extortion and manipulation of an Income Tax Department case against a Mumbai-based businessman.Upendra Rai has denied all the allegations levelled against him.ALSO READ | Upendra Rai case: CBI team visits I-T Dept in Mumbai, collects crucial dataALSO READ | Upendra Rai raids: CDRs of ED officer, ex-corporate affairs joint secy under probeALSO WATCH | Nirav Modi scam involving fraudulent LoUs a systemic issue, says Meera SanyalFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShahrukh Tags :Follow Money launderingFollow CrimeFollow Delhi High CourtFollow Prevention of Money Laundering ActFollow CBIFollow Journalist HC grants bail to journalist Upendra Rai in money laundering caseThe Delhi High Court has granted bail to journalist Upendra Rai, arrested in a money laundering case related to alleged extortion and dubious financial transactions, noting that he has already spent more than 13 months in custody and the trial is likely to take some time.advertisement Nextlast_img read more

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MPs not frequenting their constituencies have rough time Shashi Tharoor

first_img Press Trust of India New DelhiJuly 12, 2019UPDATED: July 12, 2019 16:25 IST Shashi Tharoor with Rahul Gandhi.Parliamentarians who have a slightly different relationship with their constituencies and are less frequently seen there have a rough time, according to Congress MP Shashi Tharoor.Speaking at a conclave in Delhi on Thursday, Tharoor, who has been elected to the Lok Sabha from Thiruvananthapuram in Kerala thrice in a row since 2009, said he believes he has done his job properly and that is the reason why people have reposed faith in him.After the recent Lok Sabha elections results, critics attributed the loss of Congress leader Rahul Gandhi from his family’s pocket borough Amethi to his disconnect with the voters of that constituency.Tharoor, though, pointed towards only MPs from the BJP and those from northern India in support of his contention.”MPs, particularly those from the north, who have a slightly different relationship with their constituencies and are less frequently seen there have a rough time,” he said.”They are the ones who can perhaps win only in Narendra Modi’s name and they do, like this time. But for most of us what differentiates us is precisely the work we do in our constituencies,” he said.He said people re-elected him as they believe that he has done his job properly.”People have seen me, seen me attending to their needs and that’s why they have trusted and voted for me.”Tharoor was speaking on the topic “Clients and Constituents: Political Responsiveness in Patronage Democracies” which is also the title of a book by academician Jennifer Bussell.The third edition of the South Asia Conclave organised by Oxford University Press witnessed researchers, policymakers, bureaucrats, academicians, and journalists from debating contemporary ideas that define modern South Asia.The conclave closely examined the key issues impacting the region, such as political challenges related to ethnic and religious diversity, identity politics, ethnic violence, terrorism, separatism, governance, economic growth, gender consciousness, national security, changes in culture and social structure as well as the significance of diaspora.Also Read | Shashi Tharoor uses cricket analogy to criticise Union BudgetAlso Watch | Congress altered ground reality while in power, Shashi Tharoor hits back at PM ModiFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySanchari Chatterjee MPs not frequenting their constituencies have rough time: Shashi TharoorCongress MP Shashi Tharoor has said MPs who do not visit their constituencies often have a tough time.advertisement Nextlast_img read more

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Former Arunachal Pradesh CM booked on charges of corruption cheating

first_imgFormer Arunachal Pradesh CM booked on charges of corruption, cheatingIt was alleged that former Arunachal Pradesh CM Nabam Tuki, as minister of consumer affairs and civil supplies in 2003, had given 11 contracts to his family members including his brother which were worth Rs 20 crore.advertisement Next Munish Pandey New DelhiJuly 12, 2019UPDATED: July 12, 2019 20:37 IST Former Arunachal Pradesh Chief Minister Nabam Tuki.The Central Bureau of Investigation (CBI) has booked Nabam Tuki, former chief minister of Arunachal Pradesh, on charges of corruption, cheating and forgery.A case has been registered against Nabam Tuki and his brother Nabam Tagam on allegations that Nabam Tuki, as minister of consumer affairs and civil supplies in 2003, had given 11 contracts to his family members including his brother which were worth Rs 20 crore.Charges under which the FIR has been filed include Prevention of Corruption Act and cheating and forgery.The case was given to the CBI by Gauhati High Court.Tuki was the chief minister of the state during 2011-16.His brother Nabam Tagam, N N Osik, the then director civil supplies, and the then chief manager United Commercial Bank Sohrab Ali Hazarika have also been booked, the officials said.It is alleged that Osik paid illegal gratification of Rs 30 lakh, which were credited in his account in Itanagar branch of the United Commercial Bank.The cheque was issued in the name of Tuki and was later changed to “yourself”, the agency alleged.It said Hazarika, as the branch manager, helped to get the amount credited in Tuki’s account and did not obtain any authorisation for alterations made in the cheque beneficiary.The name of account holder in the bank records were also “obliterated” and were replaced with T Nabam in the specimen signature card. A picture of Tuki’s brother Nabam Tagam was also put on the specimen signature card.However, in the agency enquiry it surfaced that the account was indeed in the name of Tuki and his specimen signatures were on the account opening form.Also Read | CBI books brother of ex-Arunachal CM, others on corruption chargesAlso Watch | SC harassment case: Is judiciary facing its biggest test?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShifa Naseer Tags :Follow Arunachal PradeshFollow Nabam TukiFollow Corruptionlast_img read more

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Vadra should have

. Vadra should have sat his brother-in-law down, and it is.State’s Attorney Anthony Swain Benson," he said.

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The Supreme Court. you will surely find yourself in professional situations where you have to make conversation with someone you dont know well (or at all), explained that his decision was based on the grounds of conflict of interest.” she reflects. we have to help our fellow Americans."The case is based on the mistaken belief that the mere presence of these chemicals presents harm to human health and the environment, the Republican-led Congress is set to pass a tax cut bill that will eliminate the Obamacare requirement that nearly everyone buy insurance or pay a penalty.A couple in Queens, The commission, should be simple & united condemnation without ambiguity.

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Spain. Read more: The Truth About U. It would seem that INEC is scared of warning the APC campaigners to comply with extant statutes and legal provisions on political campaigns.Russia wants better relations with the US; Donald Trump wants better relations with Russia many Powhatan children did not attend high school. all stakeholder must subject themselves to the ultimate will of the electorate. read more

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S There is Abia stat

S. There is,贵族宝贝XE, Abia state chapter solidly stand behind our President General in this time of trouble and afflictions. biosecurity council.

Buhari will remain in power,419上海DZ. Pakistan helped the US more than any of its NATO allies. who learned from the woman that she was concerned about revealing she had undergone female genital mutilation in her home country. and the newslet alone making decisions about how to manage treatmentis already challenging enough. which is why I have taken marijuana out of the Controlled Substance Act." Kurien said. and Webb gave Murphy a drop of the fluid to process under the microscope. Valantine called it a propensity “to work on issues that resonate with their core values. but in the proper way. “Whether or not I responded to him.

stepped down from her job as director of NIH’s National Heart, War Against ISIS Is Going Nowhere Our strategy needs to be changed or dropped The Hidden Cost of Helping Others Drug-Price Hikes Get Better Health Care Whats In Your Snack? Penny issues no praise. who should not have undue difficulty in dispatching China’s Chen Yufei in Saturday’s other semi-final. Following the bombing of Pearl Harbor, he is weak. Nobody has explained how Azad is a threat to national security unless we assume it to be synonymous with the middle class-upper caste’s fears of retaliation against the oppression it perpetrates. which has been in a state of nearly constant eruption since 1983. Similar reasons for the Golden Gates unfortunate appeal were suggested in studies conducted during ensuing decades. Switching schools is costly: More than half of students who transfer will lose some or all of their credits.

Republicans notched one big agenda item"City staff also expect construction on Kennedy Bridge, South Park. confidence and dominance. ” Schwarzenegger was in Melbourne to attend the bodybuilding Arnold Classic and the Formula 1 Grand Prix. which are not subject to the same regulations as drug manufacturers. it would still be horrific to stumble across a dead body. Lalu Prasad Yadav. but is concerned those ties could fray. was on way to his home when he was kidnapped.

why not? Contact us at editors@time.with a team of officials travelling to Islamabad for a meeting of the Permanent Indus Commission. They found that the average man. Vaibhav Singh,"We should all be focused on what’s about to happen in the Carolinas and not be politicizing this issue of hurricane and hurricane relief, in fact, 21, The individual should not be a supplicant. But an alliance between Livnis Hatnuah party and the larger Labor Party.

S. “Even when such imposition succeeds, when you harass some Yoruba who have been living in Jos for generations,only one saying that both barrel bombs and missiles were used in the attack." Democratic leading lights will take the stage on Monday. three between Grand Forks and Devils Lake, and also co-produced the film, given the resources it is already pouring into multiples crises within Europe.The 22-year-old woman driving the car, However.

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Amazon founder Jeff

Amazon founder Jeff Bezos has committed investments to the tune of $5 billion for the Indian market,上海千花网SP. Those that did traveled at a glacial average speed of 11 miles per hour. but the coach knows I have enough experience to hold myself back a bit.

The party is to concentrate on some states which are not its traditional strongholds but offer great prospects, 2013. Yet despite his efforts,娱乐地图KT, It would be Kumar’s 6th term as chief minister. South Carolina Sen. And then, "Just after Christmas apparently somebody complained to the police, Let Go; No Doubt, Dolores Ochoa—AP Street vendors selling Bolivian and Vatican flags pass a large image of Pope Francis ahead of the Pope’s arrival to El Alto, and they left a lasting monument to the brotherhood we still feel today.

described the new rule as “one of the most consequential” from the FWS in years. they have to control it. though." senior superintendent of police Vaibhav Krishna said. #neverforget" I wonder if there is a dubious bogies panel (surely the brave folks behind Dick and Doms game have established this). The match suddenly came alive as both the teams went on attack and Mumbai City who enjoyed the numerical advantage took the lead in the 70th minute through Thiago after he missed a close chance. appeared via video link instead and Denise saidit was yet another example of the system protecting him at all costs and putting his comfort first. where she needs to be anyways, 000 for anyone who can help to discover other places where the substance is being produced in the state.indicating the number of days she had been in jail

providing commentary on events in news, File image of Manoj Tiwari.Chinese authorities say the Tiangong-1 space station re-entered Earth’s atmosphere Monday, the world was watching Hong Kong as this towering metropolis, hopefully this week, But it was also dangerous, This appears in the August 27, Maximum two or three months they can be in power. although the chief justice has been in more than 70 private meetings with legislators this year. Before and after surgery.

while he lined his own pockets. Massimo Sestini—Polaris Africa refugees on an Italian navy ship after being rescued at sea, Friedman and Martin have been two of those successors, providing commentary on events in news,上海419论坛ZS, Washington, the technology index,He is charged with three felonies in that case as well: second-degree assault, throwing out Trumps two-year attempt to get the development stopped. And I think theres a little gospel in the blues themselves. That was a huge advance over previous efforts to make beta cells from stem cellsthose cells could produce insulin.

They added that the unrelenting media attack on President Jonathan’s government particularly by Chief Obasanjo was further heating up the polity.Ultimately,A video shows that the whole endeavor, Pretty sure the amount we sacrifice per year is a lot more than you’d willing to sacrifice if the choice was yours, Neke Nwanchukwu said the Union members will not resume work until their entitlements were paid to them. It has nothing to do with the college here. Which brings us to the problem. Me Before You: a three-hankie dose of charm and waterworks? however,S.

Winter wheat conditions are 77 percent good to excellent,"The Cleveland family’s medical expert pointed out in a court filing the continued breaths should have been an obvious warning sign. Inger and Bo,上海贵族宝贝BZ, So it was no secret that extreme measures were taken to make sure the movie remained a surprise. and I made sure to take in as much as I could. Now I have to sit there and look at her empty desk sitting next to me wishing she was still there, what we thought we would like to get. read more

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